An anonymous network of people affected by cancer which is free to join. It is used to treat small cell lung cancer and other cancers. Some of these patients had preexisting cardiovascular disease, and these cardiovascular side effects were attributed to the large volumes of ns used as the diluent for administration of the drug. Etopophos, innetoposide phosphate european medicines agency. Know etoposide uses, sideeffects, composition, substitutes, drug interactions, precautions, dosage, warnings only on. Etoposide oral vepesid side effects, medical uses, and. Molecular mechanisms of etoposide pubmed central pmc.
Etoposide derives from podophyllotoxin, a toxin found in the american mayapple. Pregnancy category d etoposide can cause fetal harm when administered to a pregnant woman. Advise males to use effective contraception for 4 months, after the last dose of etopophos. When these medicines are given together, drugrelated side effects reported in clinical studies give the best estimate of what to expect. Data have suggested a significant inverse correlation between serum albumin concentration and free fraction of etoposide. Our vepesid etoposide side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Etoposide side effects, dosage, interactions drugs everyday health search. Etoposide side effects, dosage, interactions drugs. Etoposide capsules etoposide dose, indications, adverse. A preparation containing etoposide phosphate can be given by intravenous injection or infusion. Etoposide toposar, vepesid, vp16 upmc hillman cancer. Side effects that you should report to your doctor or health care professional as soon as possible. Drug name mechanism of action and pharmacokinetics indications and status adverse effects dosing administration. However, for children, considering the side effects of etoposide, including.
The combination of irinotecan and etoposide was found to have modest clinical activity, with a 55% response rate by recist criteria fig. Etoposide oral chemotherapy education page 3 side effects of etoposide the common side effects that have been known to happen in more than 30% of patients taking etoposide are listed in the left side of this table. Requirement for etoposide in the initial treatment of. In a multidrug regimen, each medication has unique side effects. Toposar should be given only by slow intravenous infusion usually over a 30 to 60minute period since hypotension has been reported as a possible side effect of rapid intravenous. Effect of etoposide on the pharmacokinetics of other drugs. However, for children, considering the side effects of etoposide, including myelosuppression, teratogenesis, etc. Etoposide is an inhibitor of the enzyme topoisomerase ii, derived from podophyllum peltatum, the mayapple, a perennial herbaceous plant. Infection, especially when white blood cell count is low. If you experience a serious side effect, you or your doctor may send a. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these.
Etoposide, vp16 is a substrate for the drug transporter pglycoprotein pgp. After surviving cancer, what about late life effects of. The predominant macromolecular effect of etoposide appears to be the. Etoposide uses, side effects, substitutes, composition.
Etoposide, sold under the brand name etopophos among others, is a chemotherapy medication used for the treatments of a number of types of cancer. Call your doctor for medical advice about side effects. Myelosuppression, nausea, and vomiting are the most common adverse effects. Find patient medical information for etoposide intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. This is not a complete list of side effects and others may occur. Possible side effects of cisplatin, etoposide table version date. Etoposide fda prescribing information, side effects and uses.
Etoposide 20mgml concentrate for solution for infusion etoposide. It was first synthesized in 1966 and approved for cancer therapy in 1983 by the u. In summary, cddp treatment causes many severe late stage side effects that are tissue specific and resemble accelerated aging. Etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Etopophos etoposide injection chemotherapy, side effects. In other words, high doses may produce more severe side effects. The common side effects that have been known to happen in more than 30% of patients taking etoposide are listed in the. Toposar etoposide dose, indications, adverse effects. Instructions on how you can make a pdf version of this page using the print function on your browser. Etoposide can be administered either as intravenous infusion or in oral form. Etoposide can cause fetal harm when administered to a pregnant woman. Vepesid etoposide chemotherapy, side effects navigating care.
Etoposide phosphate side effects, dosage, interactions. Interferon can cause many different types of sideeffects including anemia. Dna strand breaks by inhibiting the action of topoisomerase ii and producing free radicals. Etoposide is usually given daily for 35 days and courses should not be repeated more frequently than at intervals of 21 days. Find information about common, infrequent and rare side effects of etoposide oral. Advise females of potential risk to the fetus and to use effective contraception during treatment with etopophos monthsand for 6 after final dose. Consumer information about the medication etoposide oral vepesid, includes side effects, drug interactions, recommended dosages, and storage information. Carboplatin and etoposide chemotherapy is used to treat small cell cancers, including small cell lung cancer, small cell bladder cancer and some types of gynaecological cancer.
Nov 09, 2018 etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Etopophos etoposide phosphate for injection is an antineoplastic agent which is available for intravenous infusion as a sterile lyophile in singledose vials containing etoposide phosphate. Clinically important side effects are in bold, italics. Oct 01, 2019 for parenteral administration, etoposide should be given only by slow intravenous infusion usually over a 30 to 60minute period, since hypotension has been reported as a possible side effect of rapid intravenous injection. If you are also having treatment with other cancer drugs, you may have some side effects that we have not listed here. Etoposide is a podophyllotoxin derivative that inhibits dna topoisomerase ii, with resultant dna strand breaks and. If you notice any other effects, check with your healthcare professional. After surviving cancer, what about late life effects of the cure. Some side effects of etoposide may occur that usually do not need medical attention. Always tell your doctor, nurse or pharmacist about any side effects you have.
Side effects are often predictable in terms of their onset and duration. Etoposide is used for small cell lung cancer, testicular cancer etc. The most prominent side effects were myelosuppression and gi toxicity. Warnings and precautions severe bone marrow depression this drug may raise your risk of getting a second cancer, such as leukemia low blood pressure with rapid infusion of the medication. You may get some of the side effects we mention, but you are unlikely to get all of them. The unbound fraction of etoposide significantly correlated with bilirubin in a population of cancer patients.
Your doctor can give you drugs to help control some side effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Jan 19, 2015 intriguingly, in resting cells inhibition of atm activity with ku55933 blocks ddr and apoptosis by preventing puma expression and caspase activation, while the same protocol increases the cytotoxic effects of etoposide on proliferating tumor cells korwek et al. Vepesid, vp16 about this drug etoposide is used to treat cancer. In addition, low grade fever and muscle aches may occur. Etoposide binding ratio correlates directly with serum albumin in patients with cancer and in normal volunteers. Tell a friend about us, add a link to this page, or visit the webmasters page for free. For parenteral administration, etoposide should be given only by slow intravenous infusion usually over a 30 to 60minute period, since hypotension has been reported as a possible.
Doctors give trusted answers on uses, effects, sideeffects, and cautions. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about. Etoposide side effects, dosage, interactions drugs everyday. Carboplatin and etoposide macmillan cancer support. Other side effects not listed may also occur in some patients. The major doselimiting toxicity of iv etoposide in the dog is hypersensitivity. To learn more about this drugs mechanism of action, click etoposide. If these drugs are used together, closely monitor for. Doctors give trusted answers on uses, effects, side effects, and cautions. Side effects of etopophos etoposide phosphate, warnings, uses. Many other medications may also interact with etoposide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. A phase ii study of irinotecan and etoposide as treatment. Most people do not experience all of the side effects listed. Side effects of etopophos etoposide phosphate, warnings.
Etoposide oral chemotherapy education page 3 side effects of etoposide the common side. Side effects are almost always reversible and will go away after treatment is complete. The following data on adverse reactions are based on both oral and intravenous administration of vepesid etoposide as a single agent, using several different. However, there are at least two case reports of hypersensitivity reactions with an alternative formulation of etoposide, etoposide. Call your doctor if you have any unusual problems while taking this medication.
Etoposide can be administered either as intravenous. Hematotoxicity, nausea and vomiting, alopecia, and a persistent metallic taste are the main sideeffects of the oral form. Possible side effects more common nausea and throwing up vomiting. A preparation containing etoposide phosphate can be given by intravenous. Etoposide may be given orally or by slow intravenous infusion, the oral dose being double the intravenous dose.
Our etopophos etoposide phosphate side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking. These symptoms may happen within one to six hours after getting this drug. Nov 09, 2018 etoposide phosphate is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body. In 100 people receiving cisplatin, etoposide, more than 20 and up to. If you experience a serious side effect, you or your doctor may send a report to the food and drug administrations fda medwatch adverse event reporting program online web or by phone 18003321088. Etoposide phosphate is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body. Etoposide definition of etoposide by the free dictionary. This includes testicular cancer, lung cancer, lymphoma, leukemia, neuroblastoma, and ovarian cancer.
For parenteral administration, etoposide should be given only by slow intravenous infusion usually over a 30 to 60minute period, since hypotension has been reported as a possible side effect of rapid intravenous injection. Interferon can cause many different types of side effects including anemia, low white blood cell counts, low platelet counts, decreased appetite, tiredness, fatigue and depression. It may be used before you get a stem cell transplant. In clinical studies, the most commonly reported carboplatin plus etoposide drug side effects are shown here. This article also covers several other topics, such as potential side effects, dosing guidelines, and general safety. Each of the side effects above was reported in 20% or greater of patients treated with etoposide. However, biliary excretion of unchanged drug andor metabolites is an important route of etoposide elimination and the unbound free.
Etoposide intravenous route side effects mayo clinic. Effect of etoposide phosphate on the pharmacokinetics of other drugs. Data have suggested a significant inverse correlation between serum albumin concentration and free. In 100 people receiving cisplatin, etoposide, more than 20 and up to 100 may have. The following adverse reactions were reported from etopophos and associated names clinical studies and. These side effects may go away during treatment as your body adjusts to the medicine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. The side effects of etoposide and their severity depend on how much of the drug is given. The following data on adverse reactions are based on both oral and intravenous administration of vepesid etoposide as a single agent, using several different dose schedules for treatment of a wide variety of malignancies.
Hlh patients, initial treatment with etoposide is essential for improving the prognosis. Apr 10, 2018 talk to your care provider or dentist before any scheduled procedures. Some of these patients had preexisting cardiovascular disease, and these cardiovascular side effects were. Specific guidelines for dosage adjustments in hepatic impairment are not provided by the manufacturer. Etopophos as 100 mg single dose preservativefree vials of lyophilized powder. Nov 16, 2016 cisplatin cddp is a frequently employed chemotherapeutic drug both in curative and palliative settings. Read more about the prescription drug etoposide oral. These side effects may go away during treatment as your body adjusts to the. Oct 12, 2017 etoposide binding ratio correlates directly with serum albumin in patients with cancer and in normal volunteers.
Jan 26, 2020 some side effects of etoposide may occur that usually do not need medical attention. Options to help manage any side effects that do occur are included on the right side of this table. Requirement for etoposide in the initial treatment of epstein. Talk to your care provider or dentist before any scheduled procedures. Etopophos etoposide phosphate for injection is an antineoplastic agent which is available for intravenous infusion as a sterile lyophile in singledose vials containing etoposide phosphate equivalent to 100 mg etoposide, 32. This article also covers several other topics, such as potential side effects, dosing guidelines, and general safety precautions to discuss with your healthcare provider before beginning treatment. Important things to remember about the side effects of etoposide. When cancer patients are cured due to cddp therapy, they unfortunately often experience severe long. You may report side effects to the fda at 1800fda1088.
442 619 1339 1346 1044 311 700 444 1456 118 252 1329 882 382 289 478 536 651 116 377 1114 1426 1588 1158 1328 282 273 1262 1321 628 642 809 440 1575 1298 1393 803 414 1194 1200 1293 1344 1491 578 530 140 114 466